Formulation & characterisation of chitosan based microspheres of Salbutamol sulphate dry powder inhaler formulation
نویسندگان
چکیده
منابع مشابه
Dry powder inhaler formulation.
A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action. For the dry powder inhaler (DPI), these goals can be met with a suitable powder formulation, an efficient metering system, and ...
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The present research was aimed to develop and characterize a sustained release dry powder inhalable formulation of salbutamol sulphate. The salbutamol sulphate microparticles were prepared by solvent evaporation method using biodegradable polymer poly (D,L-lactic-co-glycolic acid) to produce salbutamol sulphate microparticle mixed with carrier respirable grade lactose for oral inhalation of dry...
متن کاملDEM Analysis of Particle Adhesion during Powder Mixing for Dry Powder Inhaler Formulation Development
Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method (DEM), which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criter...
متن کاملFormulation and evaluation of matrix microspheres for simultaneous delivery of salbutamol sulphate and theophylline
Purpose: The objective of this study was to formulate and evaluate a matrix microsphere system for simultaneous delivery of two anti-asthmatic drugs Salbutamol sulphate and Theophylline which are often indicated for the management of asthma, their frequent dosing may reduce compliance, thus making a prolonged release formulation necessary. Ethylcellulose was used as a retardant polymer and its ...
متن کاملFormulation and Evaluation of Transdermal Films of Salbutamol Sulphate
Transdermal drug delivery systems of salbutamol sulphate using eudragit RL100 and PVP were developed by solvent casting technique employing mercury as a substrate. Propylene glycol was used as a plasticizer. The prepared films exhibited satisfactory physico-chemical characteristics. In vitro permeation profiles across the guinea-pig dorsal skin using K-C diffusion cell are reported. Incorporati...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2012
ISSN: 2250-1177
DOI: 10.22270/jddt.v2i5.292